Human growth hormone has been identified for its effect on the growth processes in the human body. Growth hormone as the name suggests itself is primarily concerned with the ideal height of an individual. Now, how does HGH actually play in the growth process?
HGH is a protein hormone that has a 190 amino acids sequence. It is a major product of the anterior pituitary gland and is produced by cells called somatotrophs. Aside from the HGH, there are other hormones that are involved in the growth process thus making it more complex than other processes. In general, the growth hormone excites tissues like the liver to secrete Insulin like Growth Factor (IGF-1). This product then stimulates the propagation of cartilage cells which results in bone growth.
In addition to this, the growth hormone has a direct effect in bone growth in the initiation of the differentiation of the cartilage cells. More than just bone growth, the IGF-1 also affects muscle growth. The IGF-1 fuels the breeding of myoblasts and stimulates protein synthesis and the uptake of amino acid.
There are different hypothesis as to how the growth hormone truly affects growth processes. All of these theories include the IGF-1 which is the mediator of GH to the actual growth processes. One of these hypotheses is the Somatomedin hypothesis. This hypothesis asserts that the GH motivates the production of the IGF-1 in the liver and other extra skeletal tissues.